Cryptanalysis of CIKS-128 and CIKS-128H Suitable for Intelligent Multimedia and Ubiquitous Computing Systems

Recently, data-dependent permutations (DDP) that are very suitable for intelligent multimedia and ubiquitous computing systems have been introduced as a new cryptographic primitive for the design of fast encryption systems. The CIKS-128 and CIKS-128H block ciphers are the typical examples of DDP-based encryption algorithms. In this paper, we show that CIKS-128 and CIKS-128H are vulnerable to related-key differential attacks. We first describe how to construct their full-round related-key differential characteristics with high probabilities and then we exploit them to break the full-round CIKS-128 and CIKS-128H with 2^44, and 2^48 data/time complexities, respectively

Economic Feasibility of Campus-Wide Photovoltaic Systems in New England

Compared to the national average residential retail electricity price, Connecticut (CT) had the 4th 26 highest electricity price in the country with 19.23 cents/kWh in September 2015, nearly 50% 27 higher than the national average for price of electricity. This study aims to assess the economic 28 feasibility of the solar PV systems at the campus under realistic constraints, by analyzing actual 29 data from the solar array on campus. The project focused on the economic feasibility of solar PV 30 systems on campus with physical, spatial, and practical constraints that result in a project to 31 deviate from theoretical (estimated) values. To achieve that, the prediction of the PV power 32 generation from the building was developed and compared with the actual (measured) data. 33 The average payback period of a campus-wide PV system was calculated as primarily 11 34 years, within a range of 8-12 years, and was estimated to reduce overall building operating 35 expenses by $250,000, or 8%. The economic parameters such as NPV and IRR also validated the 36 investment worthiness. The results of the study could be used to analyze or further develop 37 feasibility studies of PV systems at other universities in Connecticut and neighboring states that 38 share similar climatic characteristics and economic factors

Conditions for the differentiation of melanocyte-precursor cells from human cord blood-derived mesenchymal stem cells

The loss of skin pigmentation can induce compromised cutaneous immunity, which can result in conditions such as vitiligo. In this study, we evaluated various agents that are able to induce the differentiation of stem cells into melanocytes. We found that a mixture of forskolin (FK), stem cell factor (SCF) and endothelin-3 (EDN-3) induced melanocyte-like morphology in human cord blood-derived mesenchymal stem cells (CB-MSCs). In addition, significant expression of microphthalmia-associated transcription factor-M and tyrosinase-related protein-1 genes was observed. These results suggest that a mixture of FK, SCF and EDN-3 induces the differentiation of melanocyte-precursor cells (MPCs) from CB-MSCs.Keywords: mesenchymal stem cells, melanocyte-precursor cells, forskolin, microphthalmia-associated transcription factor-M, tyrosinase-related protein-1African Journal of Biotechnology Vol. 9(36), pp. 5975-5977, 6 September, 201

Exact Algorithm for the Capacitated Team Orienteering Problem with Time Windows

The capacitated team orienteering problem with time windows (CTOPTW) is a problem to determine players' paths that have the maximum rewards while satisfying the constraints. In this paper, we present the exact solution approach for the CTOPTW which has not been done in previous literature. We show that the branch-and-price (B&P) scheme which was originally developed for the team orienteering problem can be applied to the CTOPTW. To solve pricing problems, we used implicit enumeration acceleration techniques, heuristic algorithms, and ng-route relaxations

Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome.

An unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin structure and barrier function, thereby contributing to anti-aging. Metagenomic analyses showed the abundance of Streptococcus in younger individuals or those having more elastic skin. Particularly, we isolated Streptococcus pneumoniae, Streptococcus infantis, and Streptococcus thermophilus from face of young individuals. Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells. The application of culture supernatant including Streptococcal secretions on human skin showed marked improvements on skin phenotypes such as elasticity, hydration, and desquamation. Gene Ontology analysis revealed overlaps in spermidine biosynthetic and glycogen biosynthetic processes. Streptococcus-secreted spermidine contributed to the recovery of skin structure and barrier function through the upregulation of collagen and lipid synthesis in aged cells. Overall, our data suggest the role of skin microbiome into anti-aging and clinical applications

Intracoronary versus intravenous glycoprotein IIb/IIIa inhibitors during primary percutaneous coronary intervention in patients with STEMI: a systematic review and meta-analysis

Background Intracoronary (IC) administration of glycoprotein IIb/IIIa inhibitors (GPIs) has been studied as an adjunctive therapy to improve outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of IC administration of GPIs compared with those of intravenous (IV) administration in patients with STEMI. Methods We searched the MEDLINE, Embase, and Cochrane CENTRAL databases for relevant studies published before September 21, 2022. In total, 22 randomized controlled trials involving 7,699 patients were included. Results The proportions of patients achieving thrombolysis in myocardial infarction grade 3 flow, myocardial blush grade 2/3, and complete ST-segment resolution were significantly higher in the IC group than in the IV group. Major adverse cardiac events (MACE) (RR: 0.54, 95% CI: 0.37–0.80) and heart failure (RR: 0.48, 95% CI: 0.25–0.91) within 1 month were significantly lower in the IC group than in the IV group; however, after 6 months, no difference was observed in MACE risk. Additionally, the risks of death and bleeding did not differ between the two routes of administration. Conclusions When considering adjunctive GPI administration for patients with STEMI, the IC route may offer greater benefits than the IV route in terms of myocardial reperfusion and reduced occurrence of MACE and heart failure within 1 month. Nonetheless, when making decisions for IC administration of GPIs, the absence of a benefit for bleeding risk and difficulty accessing the administration route should be considere

Src Is a Prime Target Inhibited by Celtis choseniana

Celtis choseniana is the traditional plant used at Korea as a herbal medicine to ameliorate inflammatory responses. Although Celtis choseniana has been traditionally used as a herbal medicine at Korea, no systemic research has been conducted on its anti-inflammatory activity. Therefore, the present study explored an anti-inflammatory effect and its underlying molecular mechanism using Celtis choseniana methanol extract (Cc-ME) in macrophage-mediated inflammatory responses. In vitro anti-inflammatory activity of Cc-ME was evaluated using RAW264.7 cells and peritoneal macrophages stimulated by lipopolysaccharide (LPS), pam3CSK4 (Pam3), or poly(I:C). In vivo anti-inflammatory activity of Cc-ME was investigated using acute inflammatory disease mouse models, such as LPS-induced peritonitis and HCl/EtOH-induced gastritis. The molecular mechanism of Cc-ME-mediated anti-inflammatory activity was examined by Western blot analysis and immunoprecipitation using whole cell and nuclear fraction prepared from the LPS-stimulated RAW264.7 cells and HEK293 cells. Cc-ME inhibited NO production and mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and tumor necrosis factor-alpha (TNF-α) in the RAW264.7 cells and peritoneal macrophages induced by LPS, pam3, or poly(I:C) without cytotoxicity. High-performance liquid chromatography (HPLC) analysis showed that Cc-ME contained anti-inflammatory flavonoids quercetin, luteolin, and kaempferol. Among those, the content of luteolin, which showed an inhibitory effect on NO production, was highest. Cc-ME suppressed the NF-κB signaling pathway by targeting Src and interrupting molecular interactions between Src and p85, its downstream kinase. Moreover, Cc-ME ameliorated the morphological finding of peritonitis and gastritis in the mouse disease models. Therefore, these results suggest that Cc-ME exerted in vitro and in vivo anti-inflammatory activity in LPS-stimulated macrophages and mouse models of acute inflammatory diseases. This anti-inflammatory activity of Cc-ME was dominantly mediated by targeting Src in NF-κB signaling pathway during macrophage-mediated inflammatory responses